Wales will be without Aaron Ramsey, David Brooks, Tyler Roberts and Ashley Williams for the Nations League double game next week.
Juventus midfielder Ramsey, Bournemouth winger Brooks and Leeds United forward Roberts are all injured as defender Williams retires.
Ryan Giggs’ side will face Finland in Helsinki on Thursday, September 3, then host Bulgaria three days later.
Ben Woodburn and Brennan Johnson are called up by the Under-21s.
But Real Madrid’s Gareth Bale has said he is on duty as the Wales squad enter a Covid-19 bubble ahead of the Nations League matches.
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Ramsey’s absence with 60 appearances is a big blow to Giggs. The midfielder scored both goals in Wales’ last game: the 2-0 home win over Hungary last November, which nabbed a place at the end of the Euro 2020 final.
It was his only full appearance in the European qualifying campaign, but Giggs won’t want the same during the Nations League.
Brooks, who also missed the fall games, has an ankle problem and missed his club’s 2-1 friendly against Benfica in Portugal on Sunday. He would have been in contention for a starting place to win his 13th selection.
Roberts from Leeds is also missing, while center-back Williams.
currently distant who has reached the end of his contract with Bristol City, has retired for ‘personal reasons’.
Woodburn from Liverpool and Johnson from Nottingham Forest were signed by the Welsh Under-21 side, which also met in Cardiff for the European qualifiers in Bosnia and Herzegovina on Friday.
Woodburn, 20, has already made 10 appearances and two goals for the senior team and spent last season on loan at Oxford United, with the most recent Ligue 1 play-off loss to Wycombe Wanderers.
Johnson, 19, born in Nottingham, is an attacking midfielder.
who played for England Under-16s and Under-17s before moving to Wales Loyalty and joining Under-19s and Under-21s . Last season he made four appearances in England. championship with forest.
Meanwhile, Finnish center-back Paulus Arajuuri has withdrawn from the squad to face Wales next week due to injury.
Goalkeepers: Wayne Hennessey (Crystal Palace), Danny Ward (Leicester City), Adam Davies (Stoke City).
Defenders: Chris Gunter (independent), Ben Davies (Tottenham Hotspur), Connor Roberts (Swansea City), Tom Lockyer (Charlton Athletic), Ethan Ampadu (Chelsea), James Lawrence (Anderlecht), Ben Cabango (Swansea City), Neco Williams (Liverpool).
Midfielders: Jonathan Williams
(Charlton Athletic), Harry Wilson (Liverpool), Ben Woodburn (Liverpool), Matthew Smith (Manchester City), Daniel James (Manchester United), Brennan Johnson (Nottingham Forest), Will Vaulks (Cardiff City) , Joe Morrell (Bristol City), Dylan Levitt (Manchester United).
Forwards: Gareth Bale (Real Madrid), Hal Robson-Kanu (West Bromwich Albion), Rabbi Matondo (Schalke), Kieffer Moore (Cardiff City).